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Acute toxicology testing perspectives and horizons by Shayne C. Gad

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Published by Telford Press in Caldwell, N.J .
Written in English

Subjects:

  • Alternative toxicity testing.,
  • Acute toxicity testing.,
  • Animal Testing Alternatives.,
  • Drug Screening -- methods.,
  • Toxicology -- methods.

Book details:

Edition Notes

Includes bibliographies and index.

StatementShayne C. Gad and Christopher P. Chengelis.
ContributionsChengelis, Christopher P., 1949-
Classifications
LC ClassificationsRA1199.4.A38 G33 1988
The Physical Object
Paginationxiii, 530 p. :
Number of Pages530
ID Numbers
Open LibraryOL2527068M
ISBN 100936923067
LC Control Number88002295
OCLC/WorldCa17621710

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Acute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and by:   Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and Edition: 2.   Acute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and by: Acute toxicology testing provides defense against potentially dangerous chemicals. This book serves as a guide to conducting and interpreting all regulatory required and commonly used acute toxicity .

Shayne C. Gad, in Biomarkers in Toxicology (Second Edition), Acute Toxicity Studies. Acute toxicity studies are conducted to evaluate the effects of a single substance. Usually each animal receives a single dose of the test substance in this study design. 2 Notes to Table 1: a: Inhalation cut-off values in the table are based on 4 hour testing exposures. Conversion of existing inhalation toxicity data which has been generated according to 1 hour exposures should be by dividing by a factor of 2 for gases and vapours and 4 for dusts and mists.   Currently, the most successful development of stem cells as in vitro models for toxicology testing is in human cardiac tissue. , OECD GUIDELINES FOR ACUTE, SUB-CHRONIC & DERMAL TOXICITY STUDIES ACUTE • ~ Acute Oral Toxicity • ~ Acute Dermal Toxicity . Principles of Toxicology • Examines adverse effects ranging from acute to long-term • Is used to assess the probability of hazards caused by adverse effects • Is used to predict effects on individuals, populations and ecosystems. Descriptive Toxicology: The science of toxicity testing to provide information for safety evaluation and.

Series - Health Effects Test Guidelines. The final Health Effects Test Guidelines are generally intended to meet testing requirements for human health impacts of chemical substances under FIFRA and TSCA. Supplemental Guidance. Test Guidelines/Acute Toxicity - Acute Oral . • General Toxicology • Maximum tolerated dose (MTD)/Dose Range Finding (DRFs), “pivotal” and chronic toxicology studies • Design (doses, species, duration) and outcome • Regulatory documentation • Outline of general toxicology testing and general chemicals • Challenges and opportunities • Translation • Attrition. 0Reviews. The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v. Book Description Acute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and models.